ZFIN Image: Kim et al., 2007, Fig. 5

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Figure Caption

Fig. 5 Knockdown of zLrrc10 causes a decrease in the number of cardiac myocytes in developing zebrafish embryos. Transgenic zebrafish embryos expressing RFP in the cardiomyocyte nuclei (cmlc2::dsRed2-nuc) were injected with CMO or MO1. At the indicated time points, fluorescence images were captured, and cells were counted in at least ten hearts per group. Embryos were grown in the presence of 0.003% phenylthiourea from 1 dpf to inhibit pigmentation, which is effective until 4 dpf. (A, B) Representative epifluorescence images of the CMO and MO1 injected cmlc2::dsRed2-nuc transgenic zebrafish hearts at 3 dpf. (C) The number of cardiomyocytes per heart in CMO and MO1 injected embryos. Values represent means ± SEM. *p < 0.01.

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Acknowledgments

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Reprinted from Developmental Biology, 308(2), Kim, K.H., Antkiewicz, D.S., Yan, L., Eliceir, K.W., Heideman, W., Peterson, R.E., and Lee, Y., Lrrc10 is required for early heart development and function in zebrafish, 494-506, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.