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Figure Caption
Fig. 9 Knockdown of Robo3var2 MO causes morphological defects. Lateral view of live 11 hpf control (A) and (B) robo3var2 MO injected embryos (9 ng). Injecting 6–9 ng of robo3var2 MO resulted in three classes of phenotypes based on severity as visualized at 26–28 hpf. (C) Mildly affected embryos exhibited curved tails, (D) moderately affected embryos had reduced trunk tissue with tail/posterior trunk within the yolk and (E) severely affected embryos had reduced trunk tissues aggregated on the yolk. Seventy percent of the MO injected embryos showed severe to moderate phenotypes (n=300).
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Reprinted from Mechanisms of Development, 122(10), Challa, A.K., McWhorter, M.L., Wang, C., Seeger, M.A., and Beattie, C.E., Robo3 isoforms have distinct roles during zebrafish development, 1073-1086, Copyright (2005) with permission from Elsevier. Full text @ Mech. Dev.