ZFIN Image: Challa et al., 2005, Fig. 8

Image

Figure Caption

Fig. 8 Knockdown of Robo3var1 causes motor axon defects. Lateral views of (A) robo3var1 4 mm control MO and (B) robo3var1 MO injected embryos at 28 hpf labeled with znp1 antibody showing ventrally projecting CaP motor axons. Over 95% of control axons had the stereotyped curved axon morphology and reached the ventral aspect of the myotome in control embryos (A, arrow), whereas straight axons (B, asterisks) and short axons (B, arrowhead) were observed in robo3var1 MO injected embryos. (C) These data were quantitated in control MO (n=103 embryos, 1537 axons, in two experiments) and robo3var1 MO (n=228 embryos, 3527 axons, in three experiments) embryos. *P<0.05; **P<0.001.

Acknowledgments

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Reprinted from Mechanisms of Development, 122(10), Challa, A.K., McWhorter, M.L., Wang, C., Seeger, M.A., and Beattie, C.E., Robo3 isoforms have distinct roles during zebrafish development, 1073-1086, Copyright (2005) with permission from Elsevier. Full text @ Mech. Dev.