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Fig. 5
Differential regulation of nkx2.2b expression in hedgehog mutants. nkx2.2b expression in wild-type (A,B), yot (C,D), dtr (E,F), syu (G,H) and smu (I,J) 18s stage embryos. Left panel is lateral overview of embryos, right panels are dorsal views of trunk region. Small insets in left panel show lateral views of wild-type siblings from same clutch of heterozygous carriers. Note gradual loss of nkx2.2b expression in head regions of homozygous mutants. Arrowheads indicate areas with loss of nkx2.2b expression. Scale bar in (I) represents 200 µm (for A,C,E,G,I) and in (J) 30 µm (for B,D,F,H,J).
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Reprinted from Mechanisms of Development, 122(1), Schäfer, M., Kinzel, D., Neuner, C., Schartl, M., Volff, J.N., and Winkler, C., Hedgehog and retinoid signalling confines nkx2.2b expression to the lateral floor plate of the zebrafish trunk, 43-56, Copyright (2005) with permission from Elsevier. Full text @ Mech. Dev.