IMAGE

Fig. 6

ID

ZDB-IMAGE-060825-9

Genes

ptch2

Source

Figures for Koudijs et al., 2005

Image

Figure Caption

Fig. 6 Premature Stop Codons Were Identified in the uki and lep Mutant in Hip and Ptc2, Respectively
(A) Schematic representation of the genomic organization of the Hip gene. All three alleles of the uki mutation contain premature stop codons positioned in exon 5 and exon 7.
(B) Representation of the protein structure of Ptc2 shows that the identified nonsense mutation is positioned after the sixth transmembrane domain, probably resulting in a malfunctioning protein.
(C) ISH experiments show that Ptc1 expression is increased in uki and lep (arrow), confirming the aberrant activation of the Hh signaling pathway.

Figure Data

Expression / Labeling details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.