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Fig. 10 Expression of dominant-negative forms of negative regulators of Wnt signalling enhances the col mutant phenotype. (A–D) Injection of dominant-negative Xgsk-3β results in a partial loss of anterior tissue and reduced eyes in wild-type embryos (B) compared to uninjected wild-type embryos (A). The arrowhead marks a reduced, cyclopic eye in an injected wild-type embryo. Expression of dominant-negative axin (GID-2 fragment; C) and dominant-negative Xgsk-3β (D) in col mutant embryos results in a complete loss of eyes and anterior tissue. All embryos are 48 hpf.
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Reprinted from Developmental Biology, 267(1), Nambiar, R.M., and Henion, P.D., Sequential antagonism of early and late Wnt-signaling by zebrafish colgate promotes dorsal and anterior fates, 165-80, Copyright (2004) with permission from Elsevier. Full text @ Dev. Biol.