Gene
dbh
- ID
- ZDB-GENE-990621-3
- Name
- dopamine beta-hydroxylase (dopamine beta-monooxygenase)
- Symbol
- dbh Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have copper ion binding activity and dopamine beta-monooxygenase activity. Involved in sleep. Predicted to localize to extracellular space and secretory granule membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Is expressed in endocrine system; head; interrenal primordium; and nervous system. Orthologous to human DBH (dopamine beta-hydroxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 45 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
dopamine beta-hydroxylase deficiency | Alliance | Orthostatic hypotension 1, due to DBH deficiency | 223360 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR014783 | Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site |
Domain | IPR000323 | Copper type II, ascorbate-dependent monooxygenase, N-terminal |
Domain | IPR005018 | DOMON domain |
Domain | IPR024548 | Copper type II ascorbate-dependent monooxygenase, C-terminal |
Domain | IPR045266 | Copper-dependent monooxygenases, DOMON domain |
Family | IPR000945 | Dopamine beta-hydroxylase-like |
Family | IPR028460 | Tyramine beta-hydroxylase/Dopamine beta-hydroxylase |
Homologous_superfamily | IPR008977 | PHM/PNGase F domain superfamily |
Homologous_superfamily | IPR014784 | Copper type II, ascorbate-dependent monooxygenase-like, C-terminal |
Homologous_superfamily | IPR036939 | Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily |
Domain Details Per Protein
Protein | Length | Copper-dependent monooxygenases, DOMON domain | Copper type II ascorbate-dependent monooxygenase, C-terminal | Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site | Copper type II, ascorbate-dependent monooxygenase-like, C-terminal | Copper type II, ascorbate-dependent monooxygenase, N-terminal | Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily | DOMON domain | Dopamine beta-hydroxylase-like | PHM/PNGase F domain superfamily | Tyramine beta-hydroxylase/Dopamine beta-hydroxylase |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:B3DGL8
|
614 |
Interactions and Pathways
No data available
Plasmids