Gene
tpt1
- ID
- ZDB-GENE-990603-10
- Name
- tumor protein, translationally-controlled 1
- Symbol
- tpt1 Nomenclature History
- Previous Names
-
- fa28a02
- id:ibd2078
- tctp
- wu:fa28a02
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Predicted to be active in cytoplasm. Is expressed in brain; eye; lateral mesoderm; liver; and spinal cord. Orthologous to several human genes including TPT1 (tumor protein, translationally-controlled 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011184Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| zko646a | Allele with one insertion | Unknown | Unknown | CRISPR | |
| zko657b | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018103 | Translationally controlled tumour protein, conserved site |
| Domain | IPR034737 | Translationally controlled tumour protein (TCTP) domain |
| Family | IPR018105 | Translationally controlled tumour protein |
| Homologous_superfamily | IPR011057 | Mss4-like superfamily |
| Homologous_superfamily | IPR011323 | Mss4/translationally controlled tumour-associated TCTP |
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Domain Details Per Protein
| Protein | Length | Mss4-like superfamily | Mss4/translationally controlled tumour-associated TCTP | Translationally controlled tumour protein | Translationally controlled tumour protein, conserved site | Translationally controlled tumour protein (TCTP) domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q9DGK4
|
171 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-151M22 | ZFIN Curated Data | |
| Encodes | EST | fa28a02 | Gates et al., 1999 | |
| Encodes | EST | ibd2078 | ||
| Encodes | cDNA | MGC:56649 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198140 (1) | 1063 nt | ||
| Genomic | GenBank:CR339054 (2) | 184755 nt | ||
| Polypeptide | UniProtKB:Q9DGK4 (1) | 171 aa |
- Ayobahan, S.U., Eilebrecht, E., Kotthoff, M., Baumann, L., Eilebrecht, S., Teigeler, M., Hollert, H., Kalkhof, S., Schäfers, C. (2019) A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Scientific Reports. 9:6599
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Li, Z., Long, Y., Zhong, L., Song, G., Zhang, X., Yuan, L., Cui, Z., Dai, H. (2016) RNA sequencing provides insights into the toxicogenomic response of ZF4 cells to methyl methanesulfonate. Journal of applied toxicology : JAT. 36(1):94-104
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Zheng, W., Xu, H., Lam, S.H., Luo, H., Karuturi, R.K., and Gong, Z. (2013) Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. PLoS One. 8(1):e53562
- Long, Y., Li, L., Li, Q., He, X., and Cui, Z. (2012) Transcriptomic characterization of temperature stress responses in larval zebrafish. PLoS One. 7(5):e37209
- De Wit, M., Keil, D., Remmerie, N., Ven, K.V., Brandhof, E.J., Knapen, D., Witters, E., and Coen, W.D. (2008) Molecular targets of TBBPA in zebrafish analysed through integration of genomic and proteomic approaches. Chemosphere. 74(1):96-105
- Kolmakov, N.N., Kube, M., Reinhardt, R., and Canario, A.V. (2008) Analysis of the goldfish Carassius auratus olfactory epithelium transcriptome reveals the presence of numerous non-olfactory GPCR and putative receptors for progestin pheromones. BMC Genomics. 9:429
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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