Gene
pla2g4aa
- ID
- ZDB-GENE-990415-45
- Name
- phospholipase A2, group IVAa (cytosolic, calcium-dependent)
- Symbol
- pla2g4aa Nomenclature History
- Previous Names
-
- cpla2
- pla2g4
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Exhibits phospholipase activity. Involved in inflammatory response to wounding; ovarian follicle development; and regulation of G1/S transition of mitotic cell cycle. Predicted to localize to several cellular components, including Golgi apparatus; cytosol; and endoplasmic reticulum. Is expressed in brain; otic vesicle; and ovary. Orthologous to human PLA2G4A (phospholipase A2 group IVA).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Naini et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Gastrointestinal ulceration, recurrent, with dysfunctional platelets | 618372 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Acyl transferase/acyl hydrolase/lysophospholipase | C2 domain | C2 domain superfamily | Cytosolic phospholipase A2, C2 domain | Lysophospholipase, catalytic domain |
|---|---|---|---|---|---|---|
|
UniProtKB:B3DFL0
|
741 | |||||
|
UniProtKB:P50392
|
741 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pla2g4aa-201
(1)
|
Ensembl | 2,591 nt | ||
| mRNA |
pla2g4aa-202
(1)
|
Ensembl | 2,469 nt |
Interactions and Pathways
No data available
Plasmids