Gene
pla2g4aa
- ID
- ZDB-GENE-990415-45
- Name
- phospholipase A2, group IVAa (cytosolic, calcium-dependent)
- Symbol
- pla2g4aa Nomenclature History
- Previous Names
-
- cpla2
- pla2g4
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables phospholipase activity. Acts upstream of or within inflammatory response to wounding; ovarian follicle development; and regulation of G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasmic vesicle. Predicted to be active in several cellular components, including Golgi apparatus; cytosol; and endoplasmic reticulum. Is expressed in brain; otic vesicle; and ovary. Orthologous to human PLA2G4A (phospholipase A2 group IVA).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Naini et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023497Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7312 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39810 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pla2g4aa | N/A | (2) |
| MO2-pla2g4aa | N/A | (2) |
| MO3-pla2g4aa | N/A | Naini et al., 2016 |
| MO4-pla2g4aa | N/A | Huang et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Gastrointestinal ulceration, recurrent, with dysfunctional platelets | 618372 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR002642 | Lysophospholipase, catalytic domain |
| Domain | IPR041847 | Cytosolic phospholipase A2, C2 domain |
| Homologous_superfamily | IPR016035 | Acyl transferase/acyl hydrolase/lysophospholipase |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
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Domain Details Per Protein
| Protein | Length | Acyl transferase/acyl hydrolase/lysophospholipase | C2 domain | C2 domain superfamily | Cytosolic phospholipase A2, C2 domain | Lysophospholipase, catalytic domain |
|---|---|---|---|---|---|---|
|
UniProtKB:B3DFL0
|
741 | |||||
|
UniProtKB:P50392
|
741 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pla2g4aa-201
(1)
|
Ensembl | 2,591 nt | ||
| mRNA |
pla2g4aa-202
(1)
|
Ensembl | 2,469 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:pla2g4aa-mKate2) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-86N6 | ZFIN Curated Data | |
| Contained in | BAC | CH73-147D18 | ZFIN Curated Data | |
| Contained in | BAC | CH73-156H13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193527 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131295 (1) | 2591 nt | ||
| Genomic | GenBank:CU469534 | 99227 nt | ||
| Polypeptide | UniProtKB:B3DFL0 (1) | 741 aa |
- Ma, Y., Hui, K.L., Gelashvili, Z., Niethammer, P. (2023) Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish. Cell Reports. 42:111974111974
- Wang, A., Wan, X., Zhuang, P., Jia, W., Ao, Y., Liu, X., Tian, Y., Zhu, L., Huang, Y., Yao, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Jiao, J., Zhang, Y. (2023) High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2221097120e2221097120
- Cacialli, P., Mailhe, M.P., Wagner, I., Merkler, D., Golub, R., Bertrand, J.Y. (2022) Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates. The EMBO journal. 41(19):e108536
- He, B.W., Wang, F.F., Qu, L.P. (2022) Anti-Inflammatory and Antioxidant Properties of Physalis alkekengi L. Extracts In Vitro and In Vivo: Potential Application for Skin Care. Evidence-based complementary and alternative medicine : eCAM. 2022:7579572
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- J C Baker, S., Corrigan, E., Melnyk, N., Hilker, R., Van Der Kraak, G. (2021) Nuclear progesterone receptor regulates ptger4b and PLA2G4A expression in zebrafish (Danio rerio) ovulation. General and comparative endocrinology. 311:113842
- Hang, N.T., Nachtergael, A., Mai, N.T., Cornet, V., Duez, P., Muller, M., Ly Huong, D.T., Kestemont, P. (2020) Anti-inflammatory properties of the ethanol extract from Clerodendrum cyrtophyllum Turcz based on in vitro and in vivo studies. Journal of ethnopharmacology. 254:112739
- Nguyen, T.H., Le, H.D., Kim, T.N.T., The, H.P., Nguyen, T.M., Cornet, V., Lambert, J., Kestemont, P. (2020) Anti-Inflammatory and Antioxidant Properties of the Ethanol Extract of Clerodendrum Cyrtophyllum Turcz in Copper Sulfate-Induced Inflammation in Zebrafish. Antioxidants (Basel, Switzerland). 9(3):
- Ma, Y., Wu, Y., Xia, Z., Li, J., Li, X., Xu, P., Zhou, X., Xue, M. (2019) Anti-Hypoxic Molecular Mechanisms of Rhodiola crenulata Extract in Zebrafish as Revealed by Metabonomics. Frontiers in pharmacology. 10:1356
- Huang, C., Niethammer, P. (2018) Tissue Damage Signaling Is a Prerequisite for Protective Neutrophil Recruitment to Microbial Infection in Zebrafish. Immunity. 48:1006-1013.e6
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