Gene
raf1a
- ID
- ZDB-GENE-990415-41
- Name
- Raf-1 proto-oncogene, serine/threonine kinase a
- Symbol
- raf1a Nomenclature History
- Previous Names
-
- craf
- raf1
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in activation of MAPKK activity and heart development. Predicted to localize to cytosol and mitochondrion. Human ortholog(s) of this gene implicated in LEOPARD syndrome 2; Noonan syndrome (multiple); adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Is expressed in blastoderm; blastomere; and head. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Razzaque et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1NN | Alliance | Cardiomyopathy, dilated, 1NN | 615916 |
| Noonan syndrome 5 | Alliance | Noonan syndrome 5 | 611553 |
| Noonan syndrome with multiple lentigines 2 | Alliance | LEOPARD syndrome 2 | 611554 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR003116 | Raf-like Ras-binding |
| Domain | IPR020454 | Diacylglycerol/phorbol-ester binding |
| Family | IPR050167 | Serine/threonine-protein kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | C1-like domain superfamily | Diacylglycerol/phorbol-ester binding | Protein kinase, ATP binding site | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase domain | Protein kinase-like domain superfamily | Raf-like Ras-binding | Serine/threonine-protein kinase | Serine/threonine-protein kinase, active site | Serine-threonine/tyrosine-protein kinase, catalytic domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IN14
|
643 | |||||||||||
|
UniProtKB:D3KYU7
|
626 | |||||||||||
|
UniProtKB:A0A8M6Z3N3
|
611 | |||||||||||
|
UniProtKB:A0A8M9PWA5
|
628 |
Interactions and Pathways
Plasmids
No data available
- Comparative Orthology
- Alliance