Gene
nr4a2a
- ID
- ZDB-GENE-990415-184
- Name
- nuclear receptor subfamily 4, group A, member 2a
- Symbol
- nr4a2a Nomenclature History
- Previous Names
-
- nurr1
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear glucocorticoid receptor binding activity. Acts upstream of or within dopaminergic neuron differentiation; forebrain neuron development; and neutrophil homeostasis. Predicted to be located in cytoplasm and membrane. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in brain; dopaminergic neurons; and retina. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-nr4a2a,nr4a2b | N/A | Filippi et al., 2007 |
| MO2-nr4a2a | N/A | (2) |
| MO2-nr4a2a,nr4a2b | N/A | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder with language impairment and early-onset DOPA-responsive dystonia-parkinsonism | 619911 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003070 | Nuclear receptor subfamily 4 group A member 1-3 |
| Family | IPR003073 | Nuclear receptor subfamily 4 group A member 2 |
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Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Nuclear receptor subfamily 4 group A member 1-3 | Nuclear receptor subfamily 4 group A member 2 | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A9Q8C8
|
598 | |||||||
|
UniProtKB:A0A2R9YJF7
|
598 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nr4a2a-201
(1)
|
Ensembl | 3,798 nt | ||
| mRNA |
nr4a2a-202
(1)
|
Ensembl | 2,153 nt | ||
| mRNA |
nr4a2a-204
(1)
|
Ensembl | 3,656 nt | ||
| ncRNA |
nr4a2a-002
(1)
|
Ensembl | 496 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(nr4a2a:EGFP) |
|
| 1 | Goodings et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-49K16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113484 (1) | 1797 nt | ||
| Genomic | GenBank:CU179638 (2) | 137047 nt | ||
| Polypeptide | UniProtKB:A0A2R9YJF7 (1) | 598 aa |
- Altbürger, C., Holzhauser, J., Driever, W. (2023) CRISPR/Cas9-based QF2 knock-in at the tyrosine hydroxylase (th) locus reveals novel th-expressing neuron populations in the zebrafish mid- and hindbrain. Frontiers in Neuroanatomy. 17:11968681196868
- Cao, M., Wang, N., Yan, X., Yang, N., Fu, Q., Zhang, X., Zhang, Y., Li, C. (2022) Structures, evolutionary relationships and expression profiles of the tumour necrosis factor superfamily and their receptors in black rockfish (Sebastes schlegelii). Developmental and comparative immunology. 132:104405
- Gonçalves, C., Kareklas, K., Teles, M.C., Varela, S.A.M., Costa, J., Leite, R.B., Paixão, T., Oliveira, R.F. (2022) Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish. Genes, brain, and behavior. 21(5):e12809
- Vijayanathan, Y., Hamzah, N.M., Lim, S.M., Lim, F.T., Tan, M.P., Majeed, A.B.A., Ramasamy, K. (2022) Newly regenerated dopaminergic neurons IN 6-OHDA-lesioned adult zebrafish brain proliferate in the Olfactory bulb and telencephalon, but migrate to, differentiate and mature in the diencephalon. Brain research bulletin. 190:218-233
- Adusumilli, L., Facchinello, N., Teh, C., Busolin, G., Le, M.T., Yang, H., Beffagna, G., Campanaro, S., Tam, W.L., Argenton, F., Lim, B., Korzh, V., Tiso, N. (2020) miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation. Cells. 9(3):
- Wong, C.E.D., Hua, K., Monis, S., Saxena, V., Norazit, A., Noor, S.M., Ekker, M. (2020) Gdnf affects early diencephalic dopaminergic neuron development through regulation of differentiation-associated transcription factors in zebrafish. Journal of neurochemistry. 156(4):481-498
- Bruning, J.M., Wang, Y., Oltrabella, F., Tian, B., Kholodar, S.A., Liu, H., Bhattacharya, P., Guo, S., Holton, J.M., Fletterick, R.J., Jacobson, M.P., England, P.M. (2019) Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell chemical biology. 26(5):674-685.e6
- Choi, J.H., Jeong, Y.M., Kim, S., Lee, B., Ariyasiri, K., Kim, H.T., Jung, S.H., Hwang, K.S., Choi, T.I., Park, C.O., Huh, W.K., Carl, M., Rosenfeld, J.A., Raskin, S., Ma, A., Gecz, J., Kim, H.G., Kim, J.S., Shin, H.C., Park, D.S., Gerlai, R., Jamieson, B.B., Kim, J.S., Iremonger, K.J., Lee, S.H., Shin, H.S., Kim, C.H. (2018) Targeted knockout of a chemokine-like gene increases anxiety and fear responses. Proceedings of the National Academy of Sciences of the United States of America. 115(5):E1041-E1050
- Beretta, C.A., Dross, N., Guglielmi, L., Bankhead, P., Soulika, M., Gutierrez-Triana, J.A., Paolini, A., Poggi, L., Falk, J., Ryu, S., Kapsimali, M., Engel, U., Carl, M. (2017) Early Commissural Diencephalic Neurons Control Habenular Axon Extension and Targeting. Current biology : CB. 27(2):270–278
- Goodings, L., He, J., Wood, A., Harris, W.A., Currie, P.D., Jusuf, P.R. (2017) In vivo expression of Nurr1/Nr4a2a in developing retinal amacrine subtypes in zebrafish Tg(nr4a2a:eGFP) transgenics. The Journal of comparative neurology. 525(8):1962-1979
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