Gene
nr4a2a
- ID
- ZDB-GENE-990415-184
- Name
- nuclear receptor subfamily 4, group A, member 2a
- Symbol
- nr4a2a Nomenclature History
- Previous Names
-
- nurr1
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear glucocorticoid receptor binding activity. Acts upstream of or within dopaminergic neuron differentiation; forebrain neuron development; and neutrophil homeostasis. Predicted to be located in cytoplasm and membrane. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in brain; dopaminergic neurons; and retina. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder with language impairment and early-onset DOPA-responsive dystonia-parkinsonism | 619911 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003070 | Nuclear receptor subfamily 4 group A member 1-3 |
| Family | IPR003073 | Nuclear receptor subfamily 4 group A member 2 |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Nuclear receptor subfamily 4 group A member 1-3 | Nuclear receptor subfamily 4 group A member 2 | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A9Q8C8
|
598 | |||||||
|
UniProtKB:A0A2R9YJF7
|
598 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nr4a2a-201
(1)
|
Ensembl | 3,798 nt | ||
| mRNA |
nr4a2a-202
(1)
|
Ensembl | 2,153 nt | ||
| mRNA |
nr4a2a-204
(1)
|
Ensembl | 3,656 nt | ||
| ncRNA |
nr4a2a-002
(1)
|
Ensembl | 496 nt |
Interactions and Pathways
No data available
Plasmids
No data available