Gene

psmb8a

ID

ZDB-GENE-990415-141

Name

proteasome 20S subunit beta 8A

Symbol

psmb8a Nomenclature History

Previous Names

lmp7
psmb8
psmb8a (1)
beta5ia (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have endopeptidase activity. Predicted to be involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to localize to cytoplasm; nucleus; and proteasome core complex. Human ortholog(s) of this gene implicated in JMP syndrome. Orthologous to human PSMB8 (proteasome 20S subunit beta 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:85663 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With psmb8a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
proteasome-associated autoinflammatory syndrome 1	Alliance	Proteasome-associated autoinflammatory syndrome 1 and digenic forms	256040

Associated With psmb8a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR016050	Proteasome beta-type subunit, conserved site
Family	IPR000243	Peptidase T1A, proteasome beta-subunit
Family	IPR001353	Proteasome, subunit alpha/beta
Family	IPR023333	Proteasome B-type subunit
Homologous_superfamily	IPR029055	Nucleophile aminohydrolases, N-terminal

Domain Details Per Protein

Protein	Length	Nucleophile aminohydrolases, N-terminal	Peptidase T1A, proteasome beta-subunit	Proteasome beta-type subunit, conserved site	Proteasome B-type subunit	Proteasome, subunit alpha/beta
UniProtKB:O57330 InterPro	271

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ottdart00000002444 (1)	Havana	1,174 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	psmb8a-201 (1) Ensembl	Ensembl	1,226 nt	Select Tool
mRNA	psmb8a-202 (1) Ensembl	Ensembl	638 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations