Gene
acvr1ba
- ID
- ZDB-GENE-980526-527
- Name
- activin A receptor type 1Ba
- Symbol
- acvr1ba Nomenclature History
- Previous Names
-
- acvr1b
- taram-a
- tarama
- alk4 (1)
- axis
- wu:fb75f01
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable activin binding activity and activin receptor activity, type I. Acts upstream of or within dorsal/ventral pattern formation; fin regeneration; and formation of primary germ layer. Predicted to be located in membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including DEL; blastodisc; germ ring; margin; and presumptive shield. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; malignant mesothelioma; pancreatic cancer; and stomach cancer. Orthologous to human ACVR1B (activin A receptor type 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pancreatic carcinoma | Alliance | Pancreatic cancer, somatic | 260350 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000472 | Activin types I and II receptor domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR003605 | GS domain |
| Family | IPR000333 | Ser/Thr protein kinase, TGFB receptor |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR045860 | Snake toxin-like superfamily |
Domain Details Per Protein
| Protein | Length | Activin types I and II receptor domain | GS domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Ser/Thr protein kinase, TGFB receptor | Snake toxin-like superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:P79689
|
505 | ||||||||
|
UniProtKB:A0A8M2B949
|
519 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acvr1ba-201
(1)
|
Ensembl | 3,789 nt | ||
| ncRNA |
acvr1ba-002
(1)
|
Ensembl | 536 nt |
Interactions and Pathways
Plasmids