Gene
otx1
- ID
- ZDB-GENE-980526-400
- Name
- orthodenticle homeobox 1
- Symbol
- otx1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in inner ear morphogenesis; lateral semicircular canal development; and retinal pigment epithelium development. Predicted to localize to nucleus. Is expressed in several structures, including germ ring; immature eye; nervous system; neural keel; and presumptive neural plate. Orthologous to human OTX1 (orthodenticle homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 61 figures from 37 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb769 (22 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR013851 | Transcription factor Otx, C-terminal |
| Family | IPR003025 | Transcription factor Otx |
| Family | IPR003026 | Transcription factor Otx1 |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Transcription factor Otx | Transcription factor Otx1 | Transcription factor Otx, C-terminal |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B2GNW8
|
323 | ||||||
|
UniProtKB:Q91994
|
323 |
Interactions and Pathways
No data available
Plasmids
No data available