Gene
snap25b
- ID
- ZDB-GENE-980526-392
- Name
- synaptosome associated protein 25b
- Symbol
- snap25b Nomenclature History
- Previous Names
-
- snap25.2 (1)
- wu:fj33h05
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable SNAP receptor activity and syntaxin-1 binding activity. Acts upstream of or within clustering of voltage-gated sodium channels and locomotory behavior. Predicted to be located in cytoplasm and membrane. Predicted to be part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Predicted to be active in plasma membrane. Is expressed in head and nervous system. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP25 (synaptosome associated protein 25).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73101 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Moravec et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital myasthenic syndrome 18 | Alliance | ?Myasthenic syndrome, congenital, 18 | 616330 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | SNAP-25 domain | SNAP25, N-terminal SNARE motif, chordates | Target SNARE coiled-coil homology domain |
|---|---|---|---|---|
|
UniProtKB:Q6PC54
|
203 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
snap25b-201
(1)
|
Ensembl | 1,582 nt | ||
| mRNA |
snap25b-202
(1)
|
Ensembl | 609 nt | ||
| mRNA |
snap25b-203
(1)
|
Ensembl | 801 nt |
Interactions and Pathways
No data available
Plasmids
No data available