Gene

bmp2a

ID

ZDB-GENE-980526-388

Name

bone morphogenetic protein 2a

Symbol

bmp2a Nomenclature History

Previous Names

bmp2
wu:fc59d09

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable BMP receptor binding activity and cytokine activity. Acts upstream of or within exocrine pancreas development and positive regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; fin; fin bud; mesoderm; and visual system. Human ortholog(s) of this gene implicated in bone disease (multiple); hemochromatosis type 1; otosclerosis; prostate cancer; and tooth agenesis. Orthologous to human BMP2 (bone morphogenetic protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

39 figures from 30 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu125 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bmp2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
brachydactyly type A2	Alliance	Brachydactyly, type A2	112600
hemochromatosis type 1	Alliance	{HFE hemochromatosis, modifier of}	235200
short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Alliance	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	617877

Associated With bmp2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Family	IPR015615	Transforming growth factor-beta-related
Homologous_superfamily	IPR029034	Cystine-knot cytokine