Gene
ascl1b
- ID
- ZDB-GENE-980526-174
- Name
- achaete-scute family bHLH transcription factor 1b
- Symbol
- ascl1b Nomenclature History
- Previous Names
-
- ashb
- Zash-1b (1)
- zashb
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in hindbrain morphogenesis. Acts upstream of or within brain development; chordate embryonic development; and endocrine pancreas development. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; neural plate; neural tube; neurons; and posterior neural keel. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1) and ASCL2 (achaete-scute family bHLH transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 66 figures from 40 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu104 (15 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR020859 | Roc domain |
| Domain | IPR032171 | C-terminal of Roc (COR) domain |
| Family | IPR050216 | Leucine-rich repeat domain-containing protein |
| Family | IPR050283 | E-box Binding Transcriptional Regulators |
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Domain Details Per Protein
| Protein | Length | C-terminal of Roc (COR) domain | E-box Binding Transcriptional Regulators | Helix-loop-helix DNA-binding domain superfamily | Leucine-rich repeat | Leucine rich repeat 4 | Leucine-rich repeat domain-containing protein | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Myc-type, basic helix-loop-helix (bHLH) domain | P-loop containing nucleoside triphosphate hydrolase | Roc domain | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90260
|
195 | ||||||||||||
|
UniProtKB:E7F965
|
829 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ascl1b-203
(1)
|
Ensembl | 1,273 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-210P4 | ZFIN Curated Data | |
| Encodes | EST | eu104 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:85958 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131231 (1) | 1248 nt | ||
| Genomic | GenBank:BX088691 (1) | 150021 nt | ||
| Polypeptide | UniProtKB:E7F965 (1) | 829 aa |
- Liu, F., Kambakam, S., Almeida, M.P., Ming, Z., Welker, J.M., Wierson, W.A., Schultz-Rogers, L.E., Ekker, S.C., Clark, K.J., Essner, J.J., McGrail, M. (2022) Cre/lox regulated conditional rescue and inactivation with zebrafish UFlip alleles generated by CRISPR-Cas9 targeted integration. eLIFE. 11:
- Almeida, M.P., Welker, J.M., Siddiqui, S., Luiken, J., Ekker, S.C., Clark, K.J., Essner, J.J., McGrail, M. (2021) Endogenous zebrafish proneural Cre drivers generated by CRISPR/Cas9 short homology directed targeted integration. Scientific Reports. 11:1732
- Liu, K.C., Villasenor, A., Bertuzzi, M., Schmitner, N., Radros, N., Rautio, L., Mattonet, K., Matsuoka, R.L., Reischauer, S., Stainier, D.Y., Andersson, O. (2021) Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification. eLIFE. 10:
- Belzunce, I., Belmonte-Mateos, C., Pujades, C. (2020) The interplay of atoh1 genes in the lower rhombic lip during hindbrain morphogenesis. PLoS One. 15:e0228225
- Coolen, M., Labusch, M., Mannioui, A., Bally-Cuif, L. (2020) Mosaic Heterochrony in Neural Progenitors Sustains Accelerated Brain Growth and Neurogenesis in the Juvenile Killifish N. furzeri. Current biology : CB. 30(4):736-745.e4
- Messina, A., Boiti, A., Sovrano, V.A., Sgadò, P. (2020) Micromolar Valproic Acid Doses Preserve Survival and Induce Molecular Alterations in Neurodevelopmental Genes in Two Strains of Zebrafish Larvae. Biomolecules. 10(10):
- Di Bella, D.J., Carcagno, A.L., Bartolomeu, M.L., Pardi, M.B., Löhr, H., Siegel, N., Hammerschmidt, M., Marín-Burgin, A., Lanuza, G.M. (2019) Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal. Cell Reports. 28:2264-2274.e3
- Inomata, C., Yuikawa, T., Nakayama-Sadakiyo, Y., Kobayashi, K., Ikeda, M., Chiba, M., Konishi, C., Ishioka, A., Tsuda, S., Yamasu, K. (2019) Involvement of an Oct4-related PouV gene, pou5f3/pou2, in neurogenesis in the early neural plate of zebrafish embryos. Developmental Biology. 457(1):30-42
- Li, J., Dedloff, M.R., Stevens, K., Maney, L., Prochaska, M., Hongay, C.F., Wallace, K.N. (2019) A novel group of secretory cells regulates development of the immature intestinal stem cell niche through repression of the main signaling pathways driving proliferation. Developmental Biology. 456(1):47-62
- You, M.S., Wang, W.P., Wang, J.Y., Jiang, Y.J., Chi, Y.H. (2019) Sun1 mediates interkinetic nuclear migration and Notch signaling in the neurogenesis of zebrafish. Stem cells and development. 28(16):1116-1127
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