Gene
ccne1
- ID
- ZDB-GENE-980526-168
- Name
- cyclin E1
- Symbol
- ccne1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables kinase activity. Predicted to be involved in G1/S transition of mitotic cell cycle and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to act upstream of or within cell division and regulation of cell cycle. Predicted to be part of cyclin E1-CDK2 complex. Predicted to be active in centrosome; cytoplasm; and nucleus. Is expressed in anterior axial hypoblast; intestine; nervous system; notochord; and polster. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human CCNE1 (cyclin E1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55274 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb541 | Allele with one delins | Exon 6 | Unknown | CRISPR | |
| ihb542 | Allele with one deletion | Exon 6 | Unknown | CRISPR | |
| sa8454 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17090 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25369 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cyclin | Cyclin, C-terminal domain | Cyclin-like domain | Cyclin-like superfamily | Cyclin, N-terminal | Cyclins, cyclin-box |
|---|---|---|---|---|---|---|---|
|
UniProtKB:P47794
|
410 | ||||||
|
UniProtKB:B2GQF9
|
410 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-260E23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-56M16 | ZFIN Curated Data | |
| Contains | SNP | rs3728087 | ZFIN Curated Data | |
| Contains | SNP | rs3728088 | ZFIN Curated Data | |
| Contains | STS | chunp6695 | ||
| Encodes | EST | fa18e07 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55274 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86595 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191895 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130995 (1) | 2102 nt | ||
| Genomic | GenBank:CR847947 (2) | 205682 nt | ||
| Polypeptide | UniProtKB:B2GQF9 (1) | 410 aa |
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Madakashira, B.P., Magnani, E., Ranjan, S., Sadler, K.C. (2024) DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish. Nucleic acids research. 52(6):3069-3087
- Castro, V.L., Paz, D., Virrueta, V., Estevao, I.L., Grajeda, B.I., Ellis, C.C., Quintana, A.M. (2023) Missense and nonsense mutations of the zebrafish hcfc1a gene result in contrasting mTor and radial glial phenotypes. Gene. 864:147290
- Li, L., Tai, Z., Liu, W., Luo, Y., Wu, Y., Lin, S., Liu, M., Gao, B., Liu, J.X. (2023) Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. iScience. 26:106406106406
- Cao, L., Fang, H., Yan, D., Wu, X.M., Zhang, J., Chang, M.X. (2022) CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. 5:889
- Hou, C.Y., Ma, C.Y., Lin, Y.J., Huang, C.L., Wang, H.D., Yuh, C.H. (2022) WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy. International Journal of Molecular Sciences. 23(20):
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
- Chiang, K.Y., Li, Y.W., Li, Y.H., Huang, S.J., Wu, C.L., Gong, H.Y., Wu, J.L. (2021) Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish. International Journal of Molecular Sciences. 22(20):
- Choe, H., Kim, M.J., Jeon, H.J., Kim, K., Kim, C., Park, J., Shin, J., Lee, S.R., Lee, S.E. (2021) Acute toxicity of the insecticide EPN upon zebrafish (Danio rerio) embryos and its related adverse effects: Verification of abnormal cardiac development and seizure-like events. Ecotoxicology and environmental safety. 222:112544
- Jin, M., Li, J., Hu, R., Xu, B., Huang, G., Huang, W., Chen, B., He, J., Cao, Y. (2021) Cyclin A2/cyclin-dependent kinase 1-dependent phosphorylation of Top2a is required for S phase entry during retinal development in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 48(1):63-74
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