Gene

pou3f3b

ID

ZDB-GENE-980526-140

Name

POU class 3 homeobox 3b

Symbol

pou3f3b Nomenclature History

Previous Names

pou1
pou23
zp23
fb92g06
wu:fb92g06 (1)
zfpou1 (1)
zp23pou

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in X-linked deafness 2. Is expressed in nervous system; neural rod; otic vesicle; pronephric duct; and spinal cord neural tube. Orthologous to several human genes including POU3F3 (POU class 3 homeobox 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

24 figures from 14 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Barske et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pou3f3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Snijders Blok-Fisher syndrome	618604

Associated With pou3f3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR000327	POU-specific domain
Domain	IPR001356	Homeodomain
Domain	IPR013847	POU domain
Family	IPR016362	POU-domain transcription factor, class 3
Family	IPR050255	POU domain transcription factor
Homologous_superfamily	IPR009057	Homedomain-like superfamily
Homologous_superfamily	IPR010982	Lambda repressor-like, DNA-binding domain superfamily