Gene
dlb
- ID
- ZDB-GENE-980526-114
- Name
- deltaB
- Symbol
- dlb Nomenclature History
- Previous Names
-
- deltab
- etID309872.5 (1)
- sc:d0400
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable Notch binding activity. Acts upstream of or within diencephalon development and midbrain development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adenohypophyseal placode; digestive system; ectoderm; nervous system; and neural plate. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis 1. Orthologous to human DLL3 (delta like canonical Notch ligand 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 56 figures from 34 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d400 (25 images)
- eu57 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Mizoguchi et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylocostal dysostosis 1 | Alliance | Spondylocostal dysostosis 1, autosomal recessive | 277300 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001774 | Delta/Serrate/lag-2 (DSL) protein |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR011651 | Notch ligand, N-terminal domain |
| Family | IPR050906 | Notch signaling pathway |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Notch ligand, N-terminal domain | Notch signaling pathway |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:O57409
|
615 | |||||||||
|
UniProtKB:Q1LYD2
|
615 |
Interactions and Pathways
No data available
Plasmids
No data available