Gene
ckma
- ID
- ZDB-GENE-980526-109
- Name
- creatine kinase, muscle a
- Symbol
- ckma Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in extracellular space. Is expressed in brain; cardiovascular system; eye; and musculature system. Orthologous to human CKM (creatine kinase, M-type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb51 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7571 | Allele with one point mutation | Unknown | Missense | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR022415 | ATP:guanido phosphotransferase active site |
| Domain | IPR022413 | ATP:guanido phosphotransferase, N-terminal |
| Domain | IPR022414 | ATP:guanido phosphotransferase, catalytic domain |
| Family | IPR000749 | ATP:guanido phosphotransferase |
| Homologous_superfamily | IPR014746 | Glutamine synthetase/guanido kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Length | ATP:guanido phosphotransferase | ATP:guanido phosphotransferase active site | ATP:guanido phosphotransferase, catalytic domain | ATP:guanido phosphotransferase, N-terminal | ATP:guanido phosphotransferase, N-terminal domain superfamily | Glutamine synthetase/guanido kinase, catalytic domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A2BHA3
|
381 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-85K8 | ZFIN Curated Data | |
| Encodes | EST | cb51 | Thisse et al., 2001 | |
| Encodes | EST | fa28d05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65905 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77658 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130932 (1) | 1606 nt | ||
| Genomic | GenBank:BX547938 (1) | 162785 nt | ||
| Polypeptide | UniProtKB:A2BHA3 (1) | 381 aa |
- Mao, K., Li, X., Chen, Z., Dong, X., Zhangsun, D., Zhu, X., Luo, S. (2022) α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal. Frontiers in pharmacology. 13:802917
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Vecchi, V.M., Spreafico, M., Brix, A., Santoni, A., Sala, S., Pistocchi, A., Marozzi, A., Di Resta, C. (2021) Generation of a Triadin KnockOut Syndrome Zebrafish Model. International Journal of Molecular Sciences. 22(18):
- Viana, J., Wildman, N., Hannon, E., Farbos, A., Neill, P.O., Moore, K., van Aerle, R., Paull, G., Santos, E., Mill, J. (2020) Clozapine-induced transcriptional changes in the zebrafish brain. NPJ schizophrenia. 6:3
- Xiong, Y., Sun, R., Li, J., Wu, Y., Zhang, J. (2020) Latent TGF-beta binding protein-1 plays an important role in craniofacial development. Journal of applied oral science : revista FOB. 28:e20200262
- Jiao, Y., Yang, S., Min, G., Zhang, Y., Du, X., Wang, Q. (2019) Comprehensive transcriptome analysis reveal key molecular events in the pearl oyster after pre-grafting conditioning. Fish & shellfish immunology. 92:241-248
- Parolini, M., Bini, L., Magni, S., Rizzo, A., Ghilardi, A., Landi, C., Armini, A., Del Giacco, L., Binelli, A. (2018) Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 232:603-614
- Tan, J., Zhao, L., Wang, G., Li, T., Li, D., Xu, Q., Chen, X., Shang, Z., Wang, J., Zhou, J. (2018) Human MLL-AF9 Overexpression Induces Aberrant Hematopoietic Expansion in Zebrafish. BioMed Research International. 2018:6705842
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Cortelazzo, A., Pietri, T., De Felice, C., Leoncini, S., Guerranti, R., Signorini, C., Timperio, A.M., Zolla, L., Ciccoli, L., Hayek, J. (2017) Proteomic analysis of the Rett syndrome experimental model mecp2Q63X mutant zebrafish.. Journal of proteomics. 154:128-133
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