Gene

mfrp

ID

ZDB-GENE-160728-150

Name

membrane frizzled-related protein

Symbol

mfrp Nomenclature History

Previous Names

si:cabz01033205.3 (1)

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Involved in eye development. Predicted to localize to integral component of membrane. Used to study hyperopia and microphthalmia. Human ortholog(s) of this gene implicated in isolated microphthalmia 5; late-onset retinal degeneration; microphthalmia; nanophthalmos; and retinitis pigmentosa. Is expressed in ciliated epithelial cell and retinal pigmented epithelium. Orthologous to several human genes including C1QTNF5 (C1q and TNF related 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Collery et al., 2016

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Collery et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mfrp Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
isolated microphthalmia 5	Alliance	Microphthalmia, isolated 5	611040
nanophthalmos	Alliance	Nanophthalmos 2	609549

Associated With mfrp Via Experimental Models

Human Disease	Fish	Conditions	Citations
microphthalmia	mfrp^mw78/mw78	standard conditions	Collery et al., 2016
hyperopia	mfrp^mw78/mw78	standard conditions	Collery et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR000859	CUB domain
Domain	IPR020067	Frizzled domain
Homologous_superfamily	IPR035914	Spermadhesin, CUB domain superfamily
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Homologous_superfamily	IPR036790	Frizzled cysteine-rich domain superfamily
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat

Domain Details Per Protein

Protein	Length	CUB domain	Frizzled cysteine-rich domain superfamily	Frizzled domain	LDL receptor-like superfamily	Low-density lipoprotein (LDL) receptor class A, conserved site	Low-density lipoprotein (LDL) receptor class A repeat	Spermadhesin, CUB domain superfamily
UniProtKB:F1QRG7 InterPro	572
UniProtKB:A0A8M3B0L4 InterPro	311

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	si:cabz01033205.3-201 (1) Ensembl	Ensembl		2,389 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations