Gene

hpn

ID

ZDB-GENE-141212-373

Name

hepsin

Symbol

hpn Nomenclature History

Previous Names

si:ch73-124g13.3 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have scavenger receptor activity; serine-type endopeptidase activity; and serine-type exopeptidase activity. Involved in blood coagulation, fibrin clot formation and regulation of serine-type endopeptidase activity. Predicted to localize to integral component of membrane. Orthologous to human HPN (hepsin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Khandekar et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hpn Human Ortholog

No data available

Associated With hpn Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018114	Serine proteases, trypsin family, histidine active site
Active_site	IPR033116	Serine proteases, trypsin family, serine active site
Domain	IPR001190	SRCR domain
Domain	IPR001254	Serine proteases, trypsin domain
Domain	IPR015352	Hepsin, SRCR domain
Family	IPR001314	Peptidase S1A, chymotrypsin family
Homologous_superfamily	IPR009003	Peptidase S1, PA clan
Homologous_superfamily	IPR036772	SRCR-like domain superfamily
Homologous_superfamily	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold