Gene
tppp2
- ID
- ZDB-GENE-140106-24
- Name
- tubulin polymerization-promoting protein family member 2
- Symbol
- tppp2 Nomenclature History
- Previous Names
-
- tppp3l
- zmp:0000001064 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable tubulin binding activity. Acts upstream of or within axon extension. Predicted to be located in cytoplasm and cytoskeleton. Predicted to colocalize with microtubule. Is expressed in Rohon-Beard neurons; gut; and trigeminal sensory neurons. Orthologous to human TPPP2 (tubulin polymerization promoting protein family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Aoki et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Aoki et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16947 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EF-hand domain pair | Tubulin polymerization-promoting protein |
|---|---|---|---|
|
UniProtKB:E7FA56
|
181 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-110C7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001326439 (1) | 3088 nt | ||
| Genomic | GenBank:BX510647 (1) | 198695 nt | ||
| Polypeptide | UniProtKB:E7FA56 (1) | 181 aa |
- Comparative Orthology
- Alliance
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Orosz, F. (2015) On the tubulin polymerization promoting proteins of zebrafish. Biochemical and Biophysical Research Communications. 457(3):267-72
- Aoki, M., Segawa, H., Naito, M., and Okamoto, H. (2014) Identification of possible downstream genes required for the extension of peripheral axons in primary sensory neurons. Biochemical and Biophysical Research Communications. 445(2):357-362
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