Gene

adgrl1a

ID

ZDB-GENE-131127-267

Name

adhesion G protein-coupled receptor L1a

Symbol

adgrl1a Nomenclature History

Previous Names

lphn1a
si:ch211-129o13.1 (1)
zmp:0000001269

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to localize to integral component of plasma membrane. Is expressed in brain; eye; liver; and muscle. Orthologous to human ADGRL1 (adhesion G protein-coupled receptor L1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Harty et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adgrl1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Developmental delay, behavioral abnormalities, and neuropsychiatric disorders	620065

Associated With adgrl1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000203	GPS motif
Conserved_site	IPR017983	GPCR, family 2, secretin-like, conserved site
Domain	IPR000922	D-galactoside/L-rhamnose binding SUEL lectin domain
Domain	IPR001879	GPCR, family 2, extracellular hormone receptor domain
Domain	IPR003112	Olfactomedin-like domain
Domain	IPR003334	GPCR, family 2, latrophilin, C-terminal
Domain	IPR017981	GPCR, family 2-like, 7TM
Domain	IPR031234	Latrophilin-1, , transmembrane domain
Domain	IPR032471	GAIN domain, N-terminal
Family	IPR000832	GPCR, family 2, secretin-like
Family	IPR003924	GPCR, family 2, latrophilin
Homologous_superfamily	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily
Homologous_superfamily	IPR043159	D-galactoside/L-rhamnose binding SUEL lectin domain superfamily
Homologous_superfamily	IPR046338	GAIN domain superfamily

Domain Details Per Protein

Protein	Length	D-galactoside/L-rhamnose binding SUEL lectin domain	D-galactoside/L-rhamnose binding SUEL lectin domain superfamily	GAIN domain, N-terminal	GAIN domain superfamily	GPCR, family 2, extracellular hormone receptor domain	GPCR family 2, extracellular hormone receptor domain superfamily	GPCR, family 2, latrophilin	GPCR, family 2, latrophilin, C-terminal	GPCR, family 2-like, 7TM	GPCR, family 2, secretin-like	GPCR, family 2, secretin-like, conserved site	GPS motif	Latrophilin-1, , transmembrane domain	Olfactomedin-like domain
UniProtKB:A0A8M9PJK3 InterPro	722
UniProtKB:F1Q9V2 InterPro	1519
UniProtKB:A0A8M9PZN0 InterPro	1524
UniProtKB:A0A8M9PQJ9 InterPro	705

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	adgrl1a-201 (1) Ensembl	Ensembl		5,559 nt	Select Tool ZFIN BLAST
mRNA	adgrl1a-202 (1) Ensembl	Ensembl		5,574 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations