Gene

terf2ip

ID

ZDB-GENE-131121-641

Name

telomeric repeat binding factor 2, interacting protein

Symbol

terf2ip Nomenclature History

Previous Names

RAP1 (1)
zmp:0000000584

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have telomeric DNA binding activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of nucleobase-containing compound metabolic process; and telomere maintenance via telomere lengthening. Predicted to localize to cytoplasm and shelterin complex. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Orthologous to human TERF2IP (TERF2 interacting protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Wagner et al., 2017

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With terf2ip Human Ortholog

No data available

Associated With terf2ip Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001357	BRCT domain
Domain	IPR015010	TERF2-interacting telomeric protein 1, Myb domain
Domain	IPR021661	TRF2-interacting telomeric protein/Rap1, C-terminal
Family	IPR039595	TE2IP/Rap1
Homologous_superfamily	IPR009057	Homedomain-like superfamily
Homologous_superfamily	IPR036420	BRCT domain superfamily
Homologous_superfamily	IPR038104	TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily

Domain Details Per Protein

Protein	Length	BRCT domain	BRCT domain superfamily	Homedomain-like superfamily	TE2IP/Rap1	TERF2-interacting telomeric protein 1, Myb domain	TRF2-interacting telomeric protein/Rap1, C-terminal	TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily
UniProtKB:A0A8M3B5S4 InterPro	610
UniProtKB:Q6NYJ3 InterPro	616
UniProtKB:A0A8M1P1Q7 InterPro	616

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	terf2ip-201 (1) Ensembl	Ensembl	1,725 nt	Select Tool
mRNA	terf2ip-202 (1) Ensembl	Ensembl	2,481 nt	Select Tool ZFIN BLAST
mRNA	terf2ip-203 (1) Ensembl	Ensembl	2,565 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations