Gene
pdgfbb
- ID
- ZDB-GENE-131121-332
- Name
- platelet-derived growth factor beta polypeptide b
- Symbol
- pdgfbb Nomenclature History
- Previous Names
-
- sb:eu2436
- si:dkey-110g7.5
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have platelet-derived growth factor receptor binding activity. Predicted to be involved in several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; and positive regulation of protein phosphorylation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Is expressed in several structures, including basal plate midbrain region; brain; forebrain neural keel; forebrain neural rod; and notochord. Orthologous to human PDGFB (platelet derived growth factor subunit B).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2436 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
basal ganglia calcification | Alliance | Basal ganglia calcification, idiopathic, 5 | 615483 |
dermatofibrosarcoma protuberans | Alliance | Dermatofibrosarcoma protuberans | 607907 |
Meningioma, SIS-related | 607174 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site |
---|---|---|---|---|
UniProtKB:A0A8M9PEQ6
|
483 | |||
UniProtKB:A0A2R8Q0D8
|
483 | |||
UniProtKB:A0A8M9PWR6
|
482 | |||
UniProtKB:A0A8M9PRI9
|
482 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
pdgfbb-201
(1)
|
Ensembl | 3,821 nt | ||
mRNA |
pdgfbb-202
(1)
|
Ensembl | 4,898 nt | ||
mRNA |
pdgfbb-203
(1)
|
Ensembl | 7,212 nt |
Interactions and Pathways
No data available
Plasmids
No data available