Gene
hbbe1.3
- ID
- ZDB-GENE-131120-128
- Name
- hemoglobin, beta embryonic 1.3
- Symbol
- hbbe1.3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to act upstream of or within oxygen transport. Predicted to be part of hemoglobin complex. Human ortholog(s) of this gene implicated in sickle cell anemia. Orthologous to human HBE1 (hemoglobin subunit epsilon 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Globin | Globin-like superfamily | Globin/Protoglobin | Hemoglobin and related oxygen transporters | Hemoglobin, beta-type |
|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZYZ5
|
107 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hbbe1.3-201
(1)
|
Ensembl | 582 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-5K11 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001097585 (1) | |||
| Genomic | GenBank:AL935210 (1) | 88933 nt | ||
| Polypeptide | UniProtKB:Q7ZYZ5 (1) | 107 aa |
No data available
- Dong, H., Mao, L., Bai, C., Ye, K., Wu, H., Lei, Y., Yu, S., Liu, Y., Tao, J., Pan, W., Xu, H., Lin, J., Zhu, J., Dong, Q. (2022) Characterization of Developmental Neurobehavioral Toxicity in a Zebrafish MPTP-Induced Model: A Novel Mechanism Involving Anemia. ACS Chemical Neuroscience. 13(13):1877-1890
- Castillo-Castellanos, F., Ramírez, L., Lomelí, H. (2021) zmiz1a zebrafish mutants have defective erythropoiesis, altered expression of autophagy genes, and a deficient response to vitamin D. Life sciences. 284:119900
- Metikala, S., Casie Chetty, S., Sumanas, S. (2021) Single-cell transcriptome analysis of the zebrafish embryonic trunk. PLoS One. 16:e0254024
- Rajan, V., Collett, K., Woodside, R., Prykhozhij, S.V., Moksa, M., Carles, A., Wong, M., Liebman, M., Hirst, M., Berman, J.N. (2021) Stress hematopoiesis induces a proliferative advantage in TET2 deficiency. Leukemia. 36(3):809-820
- Cai, X., Zhou, Z., Zhu, J., Liao, Q., Zhang, D., Liu, X., Wang, J., Ouyang, G., Xiao, W. (2020) Zebrafish hif-3α modulates erythropoiesis via regulation of gata-1 to facilitate hypoxia tolerance. Development (Cambridge, England). 147(22):
- Palasin, K., Uechi, T., Yoshihama, M., Srisowanna, N., Choijookhuu, N., Hishikawa, Y., Kenmochi, N., Chotigeat, W. (2019) Abnormal development of zebrafish after knockout and knockdown of ribosomal protein L10a. Scientific Reports. 9:18130
- Wang, Y., Liu, X., Xie, B., Yuan, H., Zhang, Y., Zhu, J. (2019) The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Redox Biology. 28:101313
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
- Zhang, Y., Ding, Z., Zhao, G., Zhang, T., Xu, Q., Cui, B., Liu, J.X. (2018) Transcriptional responses and mechanisms of copper nanoparticle toxicology on zebrafish embryos. Journal of hazardous materials. 344:1057-1068
- Kovina, A.P., Petrova, N.V., Gushchanskaya, E.S., Dolgushin, K.V., Gerasimov, E.S., Galitsyna, A.A., Penin, A.A., Flyamer, I.M., Ioudinkova, E.S., Gavrilov, A.A., Vassetzky, Y.S., Ulianov, S.V., Iarovaia, O.V., Razin, S.V. (2017) Evolution of the genome 3D organization: comparison of fused and segregated globin gene clusters. Molecular Biology and Evolution. 34(6):1492-1504
1 - 10 of 14
Show