Gene
e2f1
- ID
- ZDB-GENE-131024-3
- Name
- E2F transcription factor 1
- Symbol
- e2f1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity; DNA-binding transcription factor activity; and protein dimerization activity. Acts upstream of with a positive effect on activation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in lung carcinoma (multiple); osteosarcoma; and pancreatic adenocarcinoma (multiple). Orthologous to human E2F1 (E2F transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhang et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003316 | E2F/DP family, winged-helix DNA-binding domain |
| Domain | IPR032198 | E2F transcription factor, CC-MB domain |
| Family | IPR015633 | E2F Family |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
| Homologous_superfamily | IPR037241 | E2F-DP heterodimerization region |
Domain Details Per Protein
| Protein | Length | E2F/DP family, winged-helix DNA-binding domain | E2F-DP heterodimerization region | E2F Family | E2F transcription factor, CC-MB domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:H9GY24
|
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|
UniProtKB:A0A8M2BLX5
|
431 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available