Gene

sv2a

ID

ZDB-GENE-131001-1

Name

synaptic vesicle glycoprotein 2A

Symbol

sv2a Nomenclature History

Previous Names

si:ch211-271d10.3

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have transmembrane transporter activity. Predicted to be involved in chemical synaptic transmission; neurotransmitter transport; and transmembrane transport. Predicted to localize to cytoplasmic vesicle; integral component of membrane; and synapse. Orthologous to human SV2A (synaptic vesicle glycoprotein 2A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Zhang et al., 2022

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Zhang et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sv2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Developmental and epileptic encephalopathy 113	620772

Associated With sv2a Via Experimental Models

Human Disease	Fish	Conditions	Citations
epilepsy	sv2a^lv105/lv105 (AB)	standard conditions	Zhang et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR005829	Sugar transporter, conserved site
Domain	IPR020846	Major facilitator superfamily domain
Family	IPR005828	Major facilitator, sugar transporter-like
Family	IPR011701	Major facilitator superfamily
Family	IPR022308	Synaptic vesicle protein SV2
Homologous_superfamily	IPR036259	MFS transporter superfamily

Domain Details Per Protein

Protein	Length	Major facilitator, sugar transporter-like	Major facilitator superfamily	Major facilitator superfamily domain	MFS transporter superfamily	Sugar transporter, conserved site	Synaptic vesicle protein SV2
UniProtKB:E7F6Z2 InterPro	733

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	sv2a-201 (1) Ensembl	Ensembl		2,202 nt	Select Tool ZFIN BLAST
mRNA	sv2a-202 (1) Ensembl	Ensembl		8,959 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations