Gene
akt1
- ID
- ZDB-GENE-130730-1
- Name
- v-akt murine thymoma viral oncogene homolog 1
- Symbol
- akt1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and protein serine/threonine kinase activity. Involved in negative regulation of neuron differentiation. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; Proteus syndrome; breast cancer (multiple); pancreatic cancer (multiple); and prostate cancer (multiple). Is expressed in central nervous system; hindbrain neural rod; pharyngeal arch; solid lens vesicle; and somite. Orthologous to human AKT1 (AKT serine/threonine kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Cheng et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| breast cancer | Alliance | Breast cancer, somatic | 114480 |
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| Cowden syndrome 6 | Alliance | Cowden syndrome 6 | 615109 |
| ovarian cancer | Alliance | Ovarian cancer, somatic | 167000 |
| Proteus syndrome | Alliance | Proteus syndrome, somatic | 176920 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR017892 | Protein kinase, C-terminal |
| Domain | IPR039026 | Protein Kinase B, pleckstrin homology domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein Kinase B, pleckstrin homology domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:M4MD44
|
474 |
- Genome Browsers
Interactions and Pathways
Plasmids
No data available