Gene

pik3ca

ID

ZDB-GENE-130409-1

Name

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Symbol

pik3ca Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have 1-phosphatidylinositol-3-kinase activity; ATP binding activity; and phosphatidylinositol bisphosphate kinase activity. Involved in regulation of collateral sprouting in absence of injury. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome; breast cancer (multiple); colorectal cancer (multiple); and cutaneous Paget's disease. Is expressed in eye. Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Schmidt et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pik3ca Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
breast cancer	Alliance	Breast cancer, somatic	114480
CLOVES syndrome	Alliance	CLOVE syndrome, somatic	612918
colorectal cancer	Alliance	Colorectal cancer, somatic	114500
Cowden syndrome 5	Alliance	Cowden syndrome 5	615108
epidermal nevus	Alliance	Nevus, epidermal, somatic	162900
hepatocellular carcinoma	Alliance	Hepatocellular carcinoma, somatic	114550
lung cancer	Alliance	Nonsmall cell lung cancer, somatic	211980
ovarian cancer	Alliance	Ovarian cancer, somatic	167000
seborrheic keratosis	Alliance	Keratosis, seborrheic, somatic	182000
stomach cancer	Alliance	Gastric cancer, somatic	613659
		Cerebral cavernous malformations 4, somatic	619538
		CLAPO syndrome, somatic	613089
		Hemifacial myohyperplasia, somatic	606773
		Macrodactyly, somatic	155500
		Megalencephaly-capillary malformation-polymicrogyria syndrome, somatic	602501

Associated With pik3ca Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
Domain	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
Domain	IPR002420	C2 phosphatidylinositol 3-kinase-type domain
Domain	IPR003113	Phosphatidylinositol 3-kinase, adaptor-binding domain
Family	IPR015433	Phosphatidylinositol kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Homologous_superfamily	IPR042236	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-type fold	C2 domain superfamily	C2 phosphatidylinositol 3-kinase-type domain	Phosphatidylinositol 3-/4-kinase, catalytic domain	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Phosphatidylinositol 3/4-kinase, conserved site	Phosphatidylinositol 3-kinase, adaptor-binding domain	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	Phosphatidylinositol kinase	Phosphoinositide 3-kinase, accessory (PIK) domain	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily	Protein kinase-like domain superfamily	Ubiquitin-like domain superfamily
UniProtKB:F1QAD7 InterPro	1069

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pik3ca-201 (1) Ensembl	Ensembl	3,684 nt	Select Tool ZFIN BLAST
mRNA	pik3ca-202 (1) Ensembl	Ensembl	4,279 nt	Select Tool
mRNA	pik3ca-203 (1) Ensembl	Ensembl	3,989 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations