Gene
agap1
- ID
- ZDB-GENE-130405-1
- Name
- ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
- Symbol
- agap1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity and GTPase activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Is expressed in cardiac ventricle. Used to study cerebral palsy. Orthologous to several human genes including AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Singh et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from van Eyk et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cerebral palsy | TU + MO1-agap1 | standard conditions | van Eyk et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001164 | Arf GTPase activating protein |
| Domain | IPR001849 | Pleckstrin homology domain |
| Family | IPR001806 | Small GTPase |
| Family | IPR051282 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Homologous_superfamily | IPR037278 | ARFGAP/RecO-like zinc finger |
| Homologous_superfamily | IPR038508 | ArfGAP domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | ArfGAP domain superfamily | ARFGAP/RecO-like zinc finger | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein | Arf GTPase activating protein | PH-like domain superfamily | Pleckstrin homology domain | P-loop containing nucleoside triphosphate hydrolase | Small GTPase |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ATA1
|
1250 | ||||||||||
|
UniProtKB:A0A8M2BGL2
|
1230 | ||||||||||
|
UniProtKB:A0A8M9Q1Y7
|
1225 | ||||||||||
|
UniProtKB:A0A8M3BAA9
|
888 | ||||||||||
|
UniProtKB:A0A8M9P952
|
1255 | ||||||||||
|
UniProtKB:A0A8M9PKA4
|
1250 | ||||||||||
|
UniProtKB:A0A8M9PRB7
|
1230 | ||||||||||
|
UniProtKB:A0A8M3AT98
|
883 | ||||||||||
|
UniProtKB:A0A8M3B0C5
|
1255 | ||||||||||
|
UniProtKB:E7FBZ7
|
858 |
Interactions and Pathways
No data available
Plasmids
No data available