Gene
tpp2
- ID
- ZDB-GENE-121214-290
- Name
- tripeptidyl peptidase 2
- Symbol
- tpp2 Nomenclature History
- Previous Names
-
- si:ch73-244f7.4
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have tripeptidyl-peptidase activity. Predicted to be involved in proteolysis. Predicted to localize to cytosol. Orthologous to human TPP2 (tripeptidyl peptidase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Yang et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Immunodeficiency 78 with autoimmunity and developmental delay | 619220 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR022398 | Peptidase S8, subtilisin, His-active site |
| Active_site | IPR023828 | Peptidase S8, subtilisin, Ser-active site |
| Domain | IPR000209 | Peptidase S8/S53 domain |
| Domain | IPR022229 | Tripeptidyl peptidase II, second Ig-like domain |
| Domain | IPR022232 | Tripeptidyl peptidase II, C-terminal domain, arthropoda |
| Domain | IPR034051 | Tripeptidyl-peptidase II domain |
| Domain | IPR048383 | Tripeptidyl-peptidase II, first Ig-like domain |
| Domain | IPR048384 | Tripeptidyl-peptidase II, galactose-binding domain-like |
| Family | IPR015500 | Peptidase S8, subtilisin-related |
| Family | IPR050131 | Subtilisin-like serine protease |
| Homologous_superfamily | IPR036852 | Peptidase S8/S53 domain superfamily |
| Homologous_superfamily | IPR046939 | Tripeptidyl-peptidase 2, C-terminal domain superfamily |
| Homologous_superfamily | IPR046940 | Tripeptidyl peptidase II, Ig-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Peptidase S8/S53 domain | Peptidase S8/S53 domain superfamily | Peptidase S8, subtilisin, His-active site | Peptidase S8, subtilisin-related | Peptidase S8, subtilisin, Ser-active site | Subtilisin-like serine protease | Tripeptidyl-peptidase 2, C-terminal domain superfamily | Tripeptidyl peptidase II, C-terminal domain, arthropoda | Tripeptidyl-peptidase II domain | Tripeptidyl-peptidase II, first Ig-like domain | Tripeptidyl-peptidase II, galactose-binding domain-like | Tripeptidyl peptidase II, Ig-like domain superfamily | Tripeptidyl peptidase II, second Ig-like domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BG24
|
1262 | |||||||||||||
|
UniProtKB:R4GDQ0
|
1263 | |||||||||||||
|
UniProtKB:A0A8M1RJV2
|
1249 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance