Gene
aldh3a1
- ID
- ZDB-GENE-120823-1
- Name
- aldehyde dehydrogenase 3 family, member A1
- Symbol
- aldh3a1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Acts upstream of or within glucose homeostasis. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome and arteriosclerosis. Orthologous to several human genes including ALDH3A2 (aldehyde dehydrogenase 3 family member A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Lou et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016160 | Aldehyde dehydrogenase, cysteine active site |
| Conserved_site | IPR029510 | Aldehyde dehydrogenase, glutamic acid active site |
| Domain | IPR015590 | Aldehyde dehydrogenase domain |
| Family | IPR012394 | Aldehyde dehydrogenase NAD(P)-dependent |
| Homologous_superfamily | IPR016161 | Aldehyde/histidinol dehydrogenase |
| Homologous_superfamily | IPR016162 | Aldehyde dehydrogenase, N-terminal |
| Homologous_superfamily | IPR016163 | Aldehyde dehydrogenase, C-terminal |
Domain Details Per Protein
| Protein | Length | Aldehyde dehydrogenase, C-terminal | Aldehyde dehydrogenase, cysteine active site | Aldehyde dehydrogenase domain | Aldehyde dehydrogenase, glutamic acid active site | Aldehyde dehydrogenase NAD(P)-dependent | Aldehyde dehydrogenase, N-terminal | Aldehyde/histidinol dehydrogenase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B3W0
|
527 | |||||||
|
UniProtKB:X1WBM4
|
489 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aldh3a1-201
(1)
|
Ensembl | 1,827 nt | ||
| mRNA |
aldh3a1-202
(1)
|
Ensembl | 4,631 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance