Gene

c5

ID

ZDB-GENE-120510-2

Name

complement component 5

Symbol

c5 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have endopeptidase inhibitor activity. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including asthma; complement component 5 deficiency; liver cirrhosis; neutropenia; and paroxysmal nocturnal hemoglobinuria. Orthologous to human C5 (complement C5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With c5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
complement component 5 deficiency	Alliance	C5 deficiency	609536
		[Eculizumab, poor response to]	615749

Associated With c5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000020	Anaphylatoxin/fibulin
Domain	IPR001134	Netrin domain
Domain	IPR001599	Alpha-2-macroglobulin
Domain	IPR002890	Macroglobulin domain
Domain	IPR009048	Alpha-macroglobulin, receptor-binding
Domain	IPR011625	Alpha-2-macroglobulin, bait region domain
Domain	IPR011626	Alpha-macroglobulin-like, TED domain
Domain	IPR018933	Netrin module, non-TIMP type
Domain	IPR040839	Macroglobulin domain MG4
Domain	IPR041425	Complement C3/4/5, macroglobulin domain MG1
Domain	IPR041555	Macroglobulin domain MG3
Domain	IPR048843	Complement component 5, CUB domain
Family	IPR050473	Alpha-2-macroglobulin/Complement system
Homologous_superfamily	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Homologous_superfamily	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR018081	Anaphylatoxin, complement system
Homologous_superfamily	IPR036595	Alpha-macroglobulin, receptor-binding domain superfamily

Domain Details Per Protein

Protein	Length	Alpha-2-macroglobulin	Alpha-2-macroglobulin, bait region domain	Alpha-2-macroglobulin/Complement system	Alpha-macroglobulin-like, TED domain	Alpha-macroglobulin, receptor-binding	Alpha-macroglobulin, receptor-binding domain superfamily	Anaphylatoxin, complement system	Anaphylatoxin/fibulin	Complement C3/4/5, macroglobulin domain MG1	Complement component 5, CUB domain	Immunoglobulin-like fold	Macroglobulin domain	Macroglobulin domain MG3	Macroglobulin domain MG4	Netrin domain	Netrin module, non-TIMP type	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid	Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:E7FCV2 InterPro	1704

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations