Gene
ptger3
- ID
- ZDB-GENE-120508-5
- Name
- prostaglandin E receptor 3 (subtype EP3)
- Symbol
- ptger3 Nomenclature History
- Previous Names
-
- im:7138942
- zPRC3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables prostaglandin E receptor activity. Involved in lymphatic endothelial cell differentiation. Acts upstream of or within positive regulation of sprouting angiogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including axial blood vessel; blastomere; endothelial cell; gonad; and hematopoietic system. Orthologous to human PTGER3 (prostaglandin E receptor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138942 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| kum1 | Allele with one deletion | Unknown | Unknown | TALEN |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Prostaglandin DP receptor | Prostanoid EP3 receptor | Prostanoid receptor |
|---|---|---|---|---|---|---|
|
UniProtKB:E7FD73
|
401 | |||||
|
UniProtKB:A0A8M9QG73
|
383 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptger3-201
(1)
|
Ensembl | 1,206 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-66A8 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7138942 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017356646 (1) | 6412 nt | ||
| Genomic | GenBank:BX324166 (1) | 215450 nt | ||
| Polypeptide | UniProtKB:E7FD73 (1) | 401 aa |
- Liu, X., Yu, T., Tan, X., Jin, D., Yang, W., Zhang, J., Dai, L., He, Z., Li, D., Zhang, Y., Liao, S., Zhao, J., Zhong, T.P., Liu, C. (2023) Renal interstitial cells promote nephron regeneration by secreting prostaglandin E2. eLIFE. 12:
- Cacialli, P., Mailhe, M.P., Wagner, I., Merkler, D., Golub, R., Bertrand, J.Y. (2022) Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates. The EMBO journal. 41(19):e108536
- FitzSimons, M., Beauchemin, M., Smith, A.M., Stroh, E.G., Kelpsch, D.J., Lamb, M.C., Tootle, T.L., Yin, V.P. (2020) Cardiac injury modulates critical components of prostaglandin E2 signaling during zebrafish heart regeneration. Scientific Reports. 10:3095
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Iwasaki, R., Tsuge, K., Kishimoto, K., Hayashi, Y., Iwaana, T., Hohjoh, H., Inazumi, T., Kawahara, A., Tsuchiya, S., Sugimoto, Y. (2019) Essential role of prostaglandin E2 and the EP3 receptor in lymphatic vessel development during zebrafish embryogenesis. Scientific Reports. 9:7650
- Chen, D., Tang, J., Wan, Q., Zhang, J., Wang, K., Shen, Y., Yu, Y. (2017) E-Prostanoid 3 Receptor Mediates Sprouting Angiogenesis Through Suppression of the Protein Kinase A/β-Catenin/Notch Pathway. Arteriosclerosis, Thrombosis, and Vascular Biology. 37(5):856-866
- Tang, H., Liu, Y., Li, J., Yin, Y., Li, G., Chen, Y., Li, S., Zhang, Y., Lin, H., Liu, X., Cheng, C.H. (2016) Gene knockout of nuclear progesterone receptor provides insights into the regulation of ovulation by LH signaling in zebrafish. Scientific Reports. 6:28545
- Wang, X., Du, X., Li, H., Zhang, S. (2016) Identification of the zinc finger protein ZRANB2 as a novel maternal LPS-binding protein that protects embryos of zebrafish against Gram-negative bacterial infections. The Journal of biological chemistry. 291(8):4019-34
- Pradhan, A., Olsson, P.E. (2014) Juvenile Ovary to Testis Transition in Zebrafish Involves Inhibition of Ptges. Biology of reproduction. 91(2):33
- Iwasaki, R., Tsuge, K., Morimoto, K., Inazumi, T., Kawahara, O., Kawahara, A., Tsuchiya, S., and Sugimoto, Y. (2013) Molecular and pharmacological characterization of zebrafish 'contractile' and 'inhibitory' prostanoid receptors. Biochemical and Biophysical Research Communications. 438(2):353-8
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