Gene

pfkfb2b

ID

ZDB-GENE-120222-1

Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b

Symbol

pfkfb2b Nomenclature History

Previous Names

fj21f03
wu:fj21f03

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to localize to cytosol. Orthologous to human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pfkfb2b Human Ortholog

No data available

Associated With pfkfb2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR001345	Phosphoglycerate/bisphosphoglycerate mutase, active site
Domain	IPR013079	6-phosphofructo-2-kinase
Family	IPR003094	Fructose-2,6-bisphosphatase
Family	IPR013078	Histidine phosphatase superfamily, clade-1
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR029033	Histidine phosphatase superfamily

Domain Details Per Protein

Protein	Length	6-phosphofructo-2-kinase	Fructose-2,6-bisphosphatase	Histidine phosphatase superfamily	Histidine phosphatase superfamily, clade-1	Phosphoglycerate/bisphosphoglycerate mutase, active site	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M9QI21 InterPro	482
UniProtKB:A0A8M9QLY8 InterPro	539
UniProtKB:X1WEG8 InterPro	548
UniProtKB:A0A8M2B1V7 InterPro	559

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pfkfb2b-201 (1) Ensembl	Ensembl	3,202 nt	Select Tool
mRNA	pfkfb2b-202 (1) Ensembl	Ensembl	537 nt	Select Tool
mRNA	pfkfb2b-203 (1) Ensembl	Ensembl	2,671 nt	Select Tool ZFIN BLAST
mRNA	pfkfb2b-204 (1) Ensembl	Ensembl	1,617 nt	Select Tool ZFIN BLAST
mRNA	pfkfb2b-205 (1) Ensembl	Ensembl	264 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations