Gene
adma
- ID
- ZDB-GENE-120221-5
- Name
- adrenomedullin a
- Symbol
- adma Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable adrenomedullin receptor binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; positive regulation of heart rate; and regulation of systemic arterial blood pressure. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in brain infarction; breast cancer; pancreatic cancer; and pulmonary hypertension. Orthologous to human ADM (adrenomedullin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Weinberger et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa21128 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Adrenomedullin-regulatory peptide | Calcitonin/adrenomedullin | Pro-adrenomedullin |
|---|---|---|---|---|
|
UniProtKB:E7F5V1
|
171 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-7I17 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001326709 (1) | 1595 nt | ||
| Genomic | GenBank:CU571259 (2) | 83418 nt | ||
| Polypeptide | UniProtKB:E7F5V1 (1) | 171 aa |
- Tsaryk, R., Yucel, N., Leonard, E.V., Diaz, N., Bondareva, O., Odenthal-Schnittler, M., Arany, Z., Vaquerizas, J.M., Schnittler, H., Siekmann, A.F. (2022) Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites. Scientific Reports. 12:4795
- Karampelias, C., Rezanejad, H., Rosko, M., Duan, L., Lu, J., Pazzagli, L., Bertolino, P., Cesta, C.E., Liu, X., Korbutt, G.S., Andersson, O. (2021) Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation. Nature communications. 12:3362
- Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264
- Weinberger, M., Simões, F.C., Patient, R., Sauka-Spengler, T., Riley, P.R. (2020) Functional Heterogeneity within the Developing Zebrafish Epicardium. Developmental Cell. 52(5):574-590.e6
- England, S.J., Campbell, P.C., Banerjee, S., Swanson, A.J., Lewis, K.E. (2017) Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes.. Frontiers in cell and developmental biology. 5:5
- Lu, J., Liu, K.C., Schulz, N., Karampelias, C., Charbord, J., Hilding, A., Rautio, L., Bertolino, P., Östenson, C.G., Brismar, K., Andersson, O. (2016) IGFBP1 increases β-cell regeneration by promoting α- to β-cell transdifferentiation. The EMBO journal. 35(18):2026-44
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
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