Gene
acvr2ab
- ID
- ZDB-GENE-120215-23
- Name
- activin A receptor type 2Ab
- Symbol
- acvr2ab Nomenclature History
- Previous Names
-
- si:dkey-264o13.1
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable activin binding activity and activin receptor activity. Predicted to be involved in activin receptor signaling pathway; cellular response to growth factor stimulus; and protein phosphorylation. Predicted to act upstream of or within phosphorylation and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Lynch syndrome and colon cancer. Orthologous to human ACVR2A (activin A receptor type 2A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Preiß et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR000333 | Ser/Thr protein kinase, TGFB receptor |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR045860 | Snake toxin-like superfamily |
Domain Details Per Protein
| Protein | Length | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Ser/Thr protein kinase, TGFB receptor | Snake toxin-like superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BGK0
|
438 | |||||
|
UniProtKB:A0A0R4ISZ9
|
439 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acvr2ab-201
(1)
|
Ensembl | 1,481 nt |
Interactions and Pathways
No data available
Plasmids
No data available