Gene
prf1.2
- ID
- ZDB-GENE-111212-3
- Name
- perforin 1.2
- Symbol
- prf1.2 Nomenclature History
- Previous Names
-
- prf19a (1)
- si:ch211-282e16.3
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity. Predicted to be involved in cytolysis and immune response. Predicted to localize to membrane attack complex. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Is expressed in gill; liver; and pleuroperitoneal region. Orthologous to human PRF1 (perforin 1).
- Genome Resources
- Note
-
Based on
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR020863 | Membrane attack complex component/perforin domain, conserved site |
Domain | IPR000008 | C2 domain |
Domain | IPR020864 | Membrane attack complex component/perforin (MACPF) domain |
Domain | IPR037300 | Perforin-1, C2 domain |
Family | IPR001862 | Membrane attack complex component/perforin/complement C9 |
Family | IPR052784 | Perforin-1 pore-forming |
Homologous_superfamily | IPR035892 | C2 domain superfamily |
Domain Details Per Protein
Protein | Length | C2 domain | C2 domain superfamily | Membrane attack complex component/perforin/complement C9 | Membrane attack complex component/perforin domain, conserved site | Membrane attack complex component/perforin (MACPF) domain | Perforin-1, C2 domain | Perforin-1 pore-forming |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A0R8WGG0
|
574 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
prf1.2-201
(1)
|
Havana | 1898 nt |
Interactions and Pathways
No data available
Plasmids
No data available