Gene
gal
- ID
- ZDB-GENE-111117-2
- Name
- galanin/GMAP prepropeptide
- Symbol
- gal Nomenclature History
- Previous Names
-
- galn
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable galanin receptor activity; galanin receptor binding activity; and neuropeptide hormone activity. Acts upstream of or within response to light stimulus and sleep. Located in neuronal cell body. Is expressed in several structures, including brain; eye; heart; pleuroperitoneal region; and spinal cord. Human ortholog(s) of this gene implicated in familial temporal lobe epilepsy 8. Orthologous to human GAL (galanin and GMAP prepropeptide).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| md76 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| o1 | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | CRISPR | |
| t12ae | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | CRISPR | |
| u515 | Allele with one delins | Unknown | Unknown | CRISPR | |
| u516 | Allele with one delins | Unknown | Unknown | CRISPR | |
| u4017 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial temporal lobe epilepsy 8 | Alliance | ?Epilepsy, familial temporal lobe, 8 | 616461 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Galanin | Galanin message associated peptide (GMAP) | Galanin precursor |
|---|---|---|---|---|
|
UniProtKB:E7EZ53
|
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-107E6 | ||
| Contained in | BAC | CH211-207N1 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001346239 (1) | 684 nt | ||
| Genomic | GenBank:CR318606 | 188531 nt | ||
| Polypeptide | UniProtKB:E7EZ53 (2) |
- Skiba, A., Kozioł, E., Luca, S.V., Budzyńska, B., Podlasz, P., Van Der Ent, W., Shojaeinia, E., Esguerra, C.V., Nour, M., Marcourt, L., Wolfender, J.L., Skalicka-Woźniak, K. (2023) Evaluation of the Antiseizure Activity of Endemic Plant Halfordia kendack Guillaumin and Its Main Constituent, Halfordin, on a Zebrafish Pentylenetetrazole (PTZ)-Induced Seizure Model. International Journal of Molecular Sciences. 24(3):
- Widelski, J., Kasica, N., Maciąg, M., Luca, S.V., Budzyńska, B., Fondai, D., Podlasz, P., Skalicka-Woźniak, K. (2023) Simple Coumarins from Peucedanum luxurians Fruits: Evaluation of Anxiolytic Activity and Influence on Gene Expression Related to Anxiety in Zebrafish Model. International Journal of Molecular Sciences. 24(10):
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Corradi, L., Bruzzone, M., Maschio, M.D., Sawamiphak, S., Filosa, A. (2022) Hypothalamic Galanin-producing neurons regulate stress in zebrafish through a peptidergic, self-inhibitory loop. Current biology : CB. 32(7):1497-1510.e5
- Reuter, A.S., Stern, D., Bernard, A., Goossens, C., Lavergne, A., Flasse, L., Von Berg, V., Manfroid, I., Peers, B., Voz, M.L. (2022) Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate. PLoS Genetics. 18:e1010109
- Ariyasiri, K., Choi, T.I., Gerlai, R., Kim, C.H. (2021) Acute ethanol induces behavioral changes and alters c-fos expression in specific brain regions, including the mammillary body, in zebrafish. Progress in neuro-psychopharmacology & biological psychiatry. 109:110264
- Karampelias, C., Rezanejad, H., Rosko, M., Duan, L., Lu, J., Pazzagli, L., Bertolino, P., Cesta, C.E., Liu, X., Korbutt, G.S., Andersson, O. (2021) Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation. Nature communications. 12:3362
- Nowik, N., Prajsnar, T.K., Przyborowska, A., Rakus, K., Sienkiewicz, W., Spaink, H.P., Podlasz, P. (2021) The Role of Galanin during Bacterial Infection in Larval Zebrafish. Cells. 10(8):
- Wiweger, M., Majewski, L., Adamek-Urbanska, D., Wasilewska, I., Kuznicki, J. (2021) npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease. Frontiers in Cellular Neuroscience. 15:647860
- Lavergne, A., Tarifeño-Saldivia, E., Pirson, J., Reuter, A.S., Flasse, L., Manfroid, I., Voz, M.L., Peers, B. (2020) Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes. BMC Biology. 18:109
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