Gene
npy2rl
- ID
- ZDB-GENE-111115-4
- Name
- neuropeptide Y receptor Y2, like
- Symbol
- npy2rl Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables neuropeptide binding activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in eye and intestine. Human ortholog(s) of this gene implicated in Huntington's disease; morbid obesity; and obesity. Orthologous to human NPY2R (neuropeptide Y receptor Y2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-npy2rl | China Zebrafish Resource Center (CZRC) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Neuropeptide Y2 receptor | Neuropeptide Y receptor family |
|---|---|---|---|---|---|
|
UniProtKB:E7F951
|
373 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
npy2rl-201
(1)
|
Ensembl | 1,563 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-24A15 | ||
| Contained in | BAC | DKEY-58J19 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001327802 (1) | 2994 nt | ||
| Genomic | GenBank:CR854964 (1) | 180969 nt | ||
| Polypeptide | UniProtKB:E7F951 (1) | 373 aa |
- Eachus, H., Oberski, L., Paveley, J., Bacila, I., Ashton, J.P., Esposito, U., Seifuddin, F., Pirooznia, M., Elhaik, E., Placzek, M., Krone, N., Cunliffe, V.T. (2023) Glucocorticoid Receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain. Disease models & mechanisms. 16(9):
- Singh, C., Rihel, J., Prober, D.A. (2017) Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling. Current biology : CB. 27(24):3796-3811.e5
- He, M.D., Zhang, F.H., Wang, H.L., Wang, H.P., Zhu, Z.Y., Sun, Y.H. (2015) Efficient ligase 3-dependent microhomology-mediated end joining repair of DNA double-strand breaks in zebrafish embryos. Mutation research. 780:86-96
- Larhammar, D., and Bergqvist, C.A. (2013) Ancient Grandeur of the Vertebrate Neuropeptide Y System Shown by the Coelacanth Latimeria chalumnae. Frontiers in neuroscience. 7:27
- Fällmar, H., Sundström, G., Lundell, I., Mohell, N., and Larhammar, D. (2011) Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 160(4):166-73
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