Gene

lgr4

ID

ZDB-GENE-111013-1

Name

leucine-rich repeat containing G protein-coupled receptor 4

Symbol

lgr4 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have transmembrane signaling receptor activity. Predicted to be involved in several processes, including bone mineralization; osteoblast differentiation; and regulation of signal transduction. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in osteoporosis. Is expressed in several structures, including Kupffer's vesicle; central nervous system; digestive system; head; and pectoral fin bud. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Mancini et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lgr4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Delayed puberty, self-limited	619613
		{Bone mineral density, low, susceptibility to}	615311

Associated With lgr4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR017452	GPCR, rhodopsin-like, 7TM
Family	IPR000276	G protein-coupled receptor, rhodopsin-like
Family	IPR002131	Glycoprotein hormone receptor family
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype