Gene
gdnfb
- ID
- ZDB-GENE-110609-2
- Name
- glial cell derived neurotrophic factor b
- Symbol
- gdnfb Nomenclature History
- Previous Names
-
- si:ch73-311f13.2
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have growth factor activity. Predicted to be involved in negative regulation of neuron apoptotic process; peripheral nervous system development; and positive regulation of branching involved in ureteric bud morphogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in Hirschsprung's disease; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Orthologous to human GDNF (glial cell derived neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Doretto et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Hirschsprung disease, susceptibility to, 3} | 613711 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | Glial cell line-derived neurotrophic factor family | Transforming growth factor-beta, C-terminal |
|---|---|---|---|---|
|
UniProtKB:A0A8M3ARX4
|
196 |
Interactions and Pathways
No data available
Plasmids
No data available