Gene

ago2

ID

ZDB-GENE-110606-6

Name

argonaute RISC catalytic component 2

Symbol

ago2 Nomenclature History

Previous Names

Ago2 (1)
eif2c2

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Exhibits miRNA binding activity and pre-miRNA binding activity. Involved in nucleate erythrocyte differentiation and pre-miRNA processing. Predicted to localize to P-body; RISC complex; and mRNA cap binding activity complex. Is expressed in several structures, including eye; fin; integument; intermediate cell mass of mesoderm; and pleuroperitoneal region. Orthologous to human AGO2 (argonaute RISC catalytic component 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ago2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Lessel-Kreienkamp syndrome	619149

Associated With ago2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003100	PAZ domain
Domain	IPR003165	Piwi domain
Domain	IPR014811	Argonaute, linker 1 domain
Domain	IPR032472	Argonaute linker 2 domain
Domain	IPR032473	Protein argonaute, Mid domain
Domain	IPR032474	Protein argonaute, N-terminal
Domain	IPR045246	Argonaute-like, PIWI domain
Family	IPR028602	Protein argonaute-2
Homologous_superfamily	IPR012337	Ribonuclease H-like superfamily
Homologous_superfamily	IPR036085	PAZ domain superfamily
Homologous_superfamily	IPR036397	Ribonuclease H superfamily