Gene

ago2

ID
ZDB-GENE-110606-6
Name
argonaute RISC catalytic component 2
Symbol
ago2 Nomenclature History
Previous Names
  • Ago2 (1)
  • eif2c2
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Exhibits miRNA binding activity and pre-miRNA binding activity. Involved in nucleate erythrocyte differentiation and pre-miRNA processing. Predicted to localize to P-body; RISC complex; and mRNA cap binding activity complex. Is expressed in several structures, including eye; fin; integument; intermediate cell mass of mesoderm; and pleuroperitoneal region. Orthologous to human AGO2 (argonaute RISC catalytic component 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ago2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Lessel-Kreienkamp syndrome 619149
Associated With ago2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003100 PAZ domain
Domain IPR003165 Piwi domain
Domain IPR014811 Argonaute, linker 1 domain
Domain IPR032472 Argonaute linker 2 domain
Domain IPR032473 Protein argonaute, Mid domain
Domain IPR032474 Protein argonaute, N-terminal
Domain IPR045246 Argonaute-like, PIWI domain
Family IPR028602 Protein argonaute-2
Homologous_superfamily IPR012337 Ribonuclease H-like superfamily
Homologous_superfamily IPR036085 PAZ domain superfamily
Homologous_superfamily IPR036397 Ribonuclease H superfamily
Domain Details Per Protein
Protein Length Argonaute-like, PIWI domain Argonaute, linker 1 domain Argonaute linker 2 domain PAZ domain PAZ domain superfamily Piwi domain Protein argonaute-2 Protein argonaute, Mid domain Protein argonaute, N-terminal Ribonuclease H-like superfamily Ribonuclease H superfamily
UniProtKB:A0A8M3AKD0 898
UniProtKB:K4I874 873
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ago2-201 (1) Ensembl 2,966 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations