Gene
taok2b
- ID
- ZDB-GENE-110603-3
- Name
- TAO kinase 2b
- Symbol
- taok2b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within cranial skeletal system development and midbrain development. Predicted to be active in cytoplasm. Is expressed in brain. Orthologous to human TAOK2 (TAO kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Blaker-Lee et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa41935 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-taok2b | Qiu et al., 2019 | |
| MO1-taok2b | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR051234 | TAO Serine/Threonine-Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | TAO Serine/Threonine-Protein Kinase |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AY27
|
1247 | |||||
|
UniProtKB:A0A0R4IIN0
|
1121 | |||||
|
UniProtKB:A0A8M3BDZ1
|
1242 | |||||
|
UniProtKB:A0A8M3AY01
|
1126 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
taok2b-201
(1)
|
Ensembl | 3,366 nt | ||
| mRNA |
taok2b-202
(1)
|
Ensembl | 3,789 nt | ||
| ncRNA |
taok2b-002
(1)
|
Ensembl | 600 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-257H3 | ZFIN Curated Data | |
| Contained in | BAC | CH211-136M16 | ZFIN Curated Data | |
| Contained in | BAC | CH211-166G5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009306401 (1) | 6355 nt | ||
| Genomic | GenBank:AL929495 (1) | 157568 nt | ||
| Polypeptide | UniProtKB:A0A8M3AY27 (1) | 1247 aa |
- Qiu, Y., Arbogast, T., Lorenzo, S.M., Li, H., Tang, S.C., Richardson, E., Hong, O., Cho, S., Shanta, O., Pang, T., Corsello, C., Deutsch, C.K., Chevalier, C., Davis, E.E., Iakoucheva, L.M., Herault, Y., Katsanis, N., Messer, K., Sebat, J. (2019) Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development. Cell Reports. 28:3320-3328.e4
- McCammon, J.M., Blaker-Lee, A., Chen, X., Sive, H. (2017) The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. Human molecular genetics. 26:3699-3712
- Blaker-Lee, A., Gupta, S., McCammon, J.M., De Rienzo, G., and Sive, H. (2012) Zebrafish homologs of 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes. Disease models & mechanisms. 5(6):834-851
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