Gene

thpo

ID
ZDB-GENE-110510-1
Name
thrombopoietin
Symbol
thpo Nomenclature History
Previous Names
  • TPO (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have cytokine activity and hormone activity. Involved in common myeloid progenitor cell proliferation and thrombocyte differentiation. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in aplastic anemia; essential thrombocythemia; and thrombocytosis. Is expressed in heart; liver; and testis. Orthologous to human THPO (thrombopoietin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Yang et al., 2022
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
szy6Allele with one delinsExon 1UnknownCRISPR
1 - 1 of 1
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-thpoYang et al., 2022
1 - 1 of 1
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Human Disease
Associated With thpo Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital amegakaryocytic thrombocytopenia 2 Alliance Amegakaryocytic thrombocytopenia, congenital, 2 620481
essential thrombocythemia Alliance Thrombocythemia 1 187950
Thrombocytopenia 9 620478
1 - 3 of 3
Associated With thpo Via Experimental Models
1 - 1 of 1
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001323 Erythropoietin/thrombopoietin
Family IPR003978 Thrombopoietin
Homologous_superfamily IPR009079 Four-helical cytokine-like, core
1 - 3 of 3
Domain Details Per Protein
Protein Length Erythropoietin/thrombopoietin Four-helical cytokine-like, core Thrombopoietin
UniProtKB:A0A8M9QF65 141
UniProtKB:B5L331 191
UniProtKB:A0A8M6Z2C6 192
1 - 3 of 3
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 2
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA thpo-201 (1) Ensembl 576 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-234E14
1 - 1 of 1
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanTHPOX
Conserved genome location (synteny) (1)
Amino acid sequence comparison (3)
MouseThpo16
Amino acid sequence comparison (2)
Citations
1 - 10 of 40
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