Gene
thpo
- ID
- ZDB-GENE-110510-1
- Name
- thrombopoietin
- Symbol
- thpo Nomenclature History
- Previous Names
-
- TPO (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have cytokine activity and hormone activity. Involved in common myeloid progenitor cell proliferation and thrombocyte differentiation. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in aplastic anemia; essential thrombocythemia; and thrombocytosis. Is expressed in heart; liver; and testis. Orthologous to human THPO (thrombopoietin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Yang et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital amegakaryocytic thrombocytopenia 2 | Alliance | Amegakaryocytic thrombocytopenia, congenital, 2 | 620481 |
| essential thrombocythemia | Alliance | Thrombocythemia 1 | 187950 |
| Thrombocytopenia 9 | 620478 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| thrombocytopenia | thposzy6/szy6; sm9Tg (AB) | standard conditions | Yang et al., 2022 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Erythropoietin/thrombopoietin | Four-helical cytokine-like, core | Thrombopoietin |
|---|---|---|---|---|
|
UniProtKB:A0A8M9QF65
|
141 | |||
|
UniProtKB:B5L331
|
191 | |||
|
UniProtKB:A0A8M6Z2C6
|
192 |
Interactions and Pathways
No data available
Plasmids