Gene

alkal1

ID

ZDB-GENE-110411-243

Name

ALK and LTK ligand 1

Symbol

alkal1 Nomenclature History

Previous Names

aug-b (1)
aug-beta (1)
fam150a (1)
si:ch73-98k10.1
si:dkey-30h22.10

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable receptor signaling protein tyrosine kinase activator activity and receptor tyrosine kinase binding activity. Acts upstream of or within iridophore differentiation. Predicted to be located in extracellular region. Orthologous to human ALKAL1 (ALK and LTK ligand 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa30901	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa41173	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
t613A	Allele with one deletion	Exon 3	Unknown	CRISPR
ya341	Allele with multiple variants	Unknown	Premature Stop	CRISPR

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Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Citations
CRISPR1-alkal1	t613A	Fadeev et al., 2018
CRISPR2-alkal1	ya341	Mo et al., 2017
CRISPR3-alkal1	ya341	Mo et al., 2017
CRISPR4-alkal1	ya341	Mo et al., 2017

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Human Disease

Associated With alkal1 Human Ortholog

No data available

Associated With alkal1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR029364	ALK and LTK ligand 1/2

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Domain Details Per Protein

Protein	Length	ALK and LTK ligand 1/2
UniProtKB:F8W2C9 InterPro	152
UniProtKB:A0A8M2BEE7 InterPro	151

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 8

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	alkal1-201 (1) Ensembl	Ensembl	2,493 nt	Select Tool ZFIN BLAST
mRNA	alkal1-202 (1) Ensembl	Ensembl	755 nt	Select Tool ZFIN BLAST
mRNA	alkal1-203 (1) Ensembl	Ensembl	819 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-98K10	CT583703	ZFIN Curated Data
Contained in	BAC	DKEY-30H22	AL844185	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001423855 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:AL844185 (1)	180872 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F8W2C9 (1)	152 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance

Species	Symbol	Chromosome	Accession #	Evidence
Human	ALKAL1	8	Ensembl:ENSG00000196711 Gene:389658 OMIM:619670 HGNC:33775	Phylogenetic tree (1) Amino acid sequence comparison (2)
Mouse	Alkal1	1	Ensembl:ENSMUSG00000087247 MGI:3645495 Gene:620393	Amino acid sequence comparison (2) Phylogenetic tree (1)

Citations

Include unpublished citations

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