Gene
cers2b
- ID
- ZDB-GENE-110408-40
- Name
- ceramide synthase 2b
- Symbol
- cers2b Nomenclature History
- Previous Names
-
- si:ch211-167h2.3
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable sphingosine N-acyltransferase activity. Acts upstream of or within cellular response to ceramide. Predicted to be located in endoplasmic reticulum membrane and nucleus. Is expressed in several structures, including brain; lens placode; mesoderm; pleuroperitoneal region; and solid lens vesicle. Orthologous to human CERS2 (ceramide synthase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cers2b | Mendelson et al., 2017 | |
| MO1-cers2b | N/A | Mendelson et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeodomain | Sphingosine N-acyltransferase Lag1/Lac1-like | TRAM/LAG1/CLN8 homology domain |
|---|---|---|---|---|---|
|
UniProtKB:E7F9X7
|
383 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cers2b-201
(1)
|
Ensembl | 3,762 nt | ||
| mRNA |
cers2b-202
(1)
|
Ensembl | 5,682 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-167H2 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_688576 (1) | 1647 nt | ||
| Genomic | GenBank:BX005277 (1) | 137475 nt | ||
| Polypeptide | UniProtKB:E7F9X7 (1) | 383 aa |
- Sun, S., Cao, X., Gao, J. (2021) C24:0 avoids cold exposure-induced oxidative stress and fatty acid β-oxidation damage. iScience. 24:103409
- Mendelson, K., Pandey, S., Hisano, Y., Carellini, F., Das, B., Hla, T., Evans, T. (2017) The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine Levels during zebrafish embryogenesis. eLIFE. 6
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Brondolin, M., Berger, S., Reinke, M., Tanaka, H., Ohshima, T., Fuss, B., and Hoch, M. (2013) Identification and expression analysis of the zebrafish homologs of the ceramide synthase gene family. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(2):189-200
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